c-MET相关论文
目的 探讨肝细胞肝癌（hepatocelluar carcinoma, HCC）中c-Met、Fascin及CD44的表达与临床病理特征及预后之间的关系。方法 从癌症基......
研究背景:耐药与侵袭转移是临床上肺癌治疗失败的主要原因,研究表明表皮生长因子（Epidermal Growth Factor Receptor,EGFR）非敏感突......
研究背景:多靶点酪氨酸激酶抑制剂（TKI）索拉非尼是经美国食品药品监督管理局（FDA）批准的可用于晚期肝细胞性肝癌（HCC）病人的一线药品,索......
c-Mesenchymal-epithelial transition（c-Met）激酶是一种独特的具有多效性的蛋白质受体酪氨酸激酶（RTKs）。它在癌症进展、肿瘤发生和治......
c-Met-targeted chimeric antigen receptor T cells inhibit hepatocellular carcinoma cells in vitro and
c-Met is a hepatocyte growth factor receptor overexpressed in many tumors such as hepatocellular carcinoma(HCC).Therefor......
肺癌是我国发病率和死亡率增长最快、对人群健康和生命威胁最大的恶性肿瘤之一,其中约80％是NSCLC[1].随着分子生物学的发展,靶向治......
c-Met是酪氨酸激酶受体的一种,由MET基因编码产生.肝细胞生长因子(HGF)作为c-Met唯一的天然配体,与其结合后激活相关下游通路如PI3......
目的:我们前期通过全基因组Cas9筛选与表达谱芯片分析发现c-Met与肝细胞癌（HCC）对索拉非尼耐药密切相关。本研究分析c-Met表达与HCC......
Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B vir
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功能核酸是指除了具备传统核酸分子的遗传信息存储功能之外,还具有特异性识别以及高效催化等其他特殊功能的核酸分子,主要包括apta......
目的 基于多肽类分子探针的c-Met靶向分子成像 方法 一,构建基于c-Met靶向多肽的分子探针,对筛选自多肽展示库并已知具有c-Met靶向......
Purpose Research of c-Met targeted molecular imaging based on targeted peptide Method 1 Construction of c-Met targeted m......
目的 基于生物信息大数据挖掘分析c-MET(c-mesenchymal-epithelial transition)在胰腺癌中的表达及临床意义。方法 检索 Oncomine ......
目的 组蛋白去乙酰化酶抑制剂(Histone deacetylase inhibitor,HDACi)是靶向表观遗传的一类新型抑制剂,已应用于多种亚型血液肿瘤......
目的 c-Met(肝细胞生长因子受体)受体属于酪氨酸激酶型受体，广泛参与细胞增殖、凋亡等生命活动[1]。研究表明，异常情况下c-Met 基因......
目的 目前,胃癌靶向治疗药物中,阿帕替尼等VEGFR2 抑制剂具有着突出作用。然而,在VEGFR2抑制剂使用过程中,VEGFR2 抑制剂的耐药却......
目的 一个54岁的男性患者于2013年6月被确诊为晚期腺状细胞癌后,先后进行不同方案的药物化疗,期间并口服特罗凯、AZD9291、易瑞沙......
Down-regulation of c-Met and Bcl2 by MicroRNA-206,Activates Apoptosis, and Inhibits Tumor Cell Proli
Objective: Hsa-miRNA-206 (miR-206), highly expressed inskeletal muscle, has recently been discovered to have anticancer ......
C-MET regulates epithelial-to-mesenchymal transition and invasion of drug-resistance in gastric canc
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目的 检测肺癌患者的常规经支气管穿刺活检(conventional transbronchial needle aspiration,C-TBNA)样本中c-met、c-myc、VEGF和T......
会议
Design,synthesis,and Antitumor Activity of novel quinoline and 1,2-dihydroquinoline derivatives conn
A series of novel quinoline and 1,2-dihydroquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthe......
The study aimed to explore the specific function and mechanism of miR-144-3p in glioblastoma (GBM) cells with different ......
c-Met is one of receptor tyrosine kinase,expressed in normal and tumor cells are present [1].In human cancers,c-Met sign......
c-Met酪氨酸蛋白激酶是由Met原癌基因编码的一种细胞表面受体即肝细胞受体生长因子受体.HGF-Met信号通路的激活可促进肿瘤细胞生长......
根据已报道的双环三氮唑类c-Met抑制剂的结构特征,运用传统的药物化学和计算机辅助设计策略,通过生物电子等排原理设计合成了结构......
c-Met identifies a population of matrix metalloproteinase 9-producing monocytes in peritumoral strom
Macrophages (Mφ) are prominent components of solid tumors and exhibit distinct phenotypes in different microenvironment......
Molecular Mechanism for Phosphorylated c-MET Recognition of SHIP2 SH2 Domain Revealed by NMR Spectro
The SH2 domain-containing inositol 5-phosphatase 2(SHIP2)hydrolyzes the 5-phosphate of PtdIns(3,4,5)P3 to produce PtdIns......
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Macrophages (Mφ) are prominent components of solid tumors and exhibit distinct phenotypes in different microenvironment......
目的：观察抗纤抑癌方对肝癌前病变大鼠HGF/c-Met mRNA的影响,探讨抗纤抑癌方防治肝癌前病变的作用机制.方法：75只SD雄性大鼠随机分为......
The molecular mechanisms underlying colorectal cancer(CRC)development remain elusive.In this study,we examined the miRNA......
Background: Immunohistochemistry(IHC)and fluorescent in situ hybridization(FISH)are reliable ways to identify overexpres......
The Radiosensitizing Effects of TKI at Different Administration Schedules are Related to PI3K Signal
The optimal administration time when tyrosine kinase inhibitor (TKI) combined with radiotherapy is unclear until today.T......
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Molecular Imaging of Mesenchymal Epithelial Transition Receptor (c-Met)Expression Using a Novel 18F-
The mesenchymal epithelial transition factor (c-Met) is a member of the tyrosine kinase growth factor receptor family.Ap......
背景:非小细胞肺癌(non-smallcelllungcancer,NSCLC)是全球范围内发病率和死亡率最高的恶性肿瘤之一,多数患者确诊时已属晚期,传统......
目的检测胰腺癌组织及BxPC3细胞的miR-34a表达，明确其靶基因，分析miR-34a及其靶基因的表达与胰腺癌临床病理参数的关系以及对BxPC3细......
食管癌是我国常见的消化道肿瘤，预后差。放疗是食管癌的主要治疗方式，肿瘤的放射敏感性是影响放疗疗效的一个重要原因。肝细胞生长因......
目的 探讨c-Met、Survivin在大肠癌中的表达以及二者与肿瘤血管生成的关系.方法 选取经病理证实的5l例大肠腺癌(直肠癌22例,结肠癌......
目的探讨肝细胞生长因子（HGF）及其受体c-Met在结直肠癌组织中的表达及其临床意义。方法以2012年3月至2015年2月接受治疗的100例结直......
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目的:制备人源抗c-Met的全分子抗体(c-Met-IgG1)及其与重组东亚钳蝎镇痛抗肿瘤多肽(recombinant analgesic-antitumor peptide,rAG......
血管拟态(Vasculogenic Mimicry,VM)是一种不依赖与内皮细胞而独立存在于肿瘤内部为其提供血供的脉管系统,是内皮依赖型脉管系......
